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A chemical that rid mice of malaria-causing parasites after a single oral dose may eventually become a new malaria drug if further tests in animals and people uphold the promise of early findings. The compound, NITD609, was developed by an international team of researchers including Elizabeth A. Winzeler, Ph.D., a grantee of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
DURHAM, N.C. – Duke University Medical Center researchers have found two genes in mice which might help identify why some people are more susceptible than others to potentially deadly staph infections.
The discovery could lead to development of a simple dietary remedy for many of the more than 23 million Americans suffering from diabetes and other conditions.
Kidney transplants that show a combination of fibrosis (scarring) and inflammation after one year are at higher risk of long-term transplant failure, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).
Athens, Ga. – Stem cells might be thought of as trunks in the tree of life. All multi-cellular organisms have them, and they can turn into a dazzling variety other cells—kidney, brain, heart or skin, for example. One class, pluripotent stem cells, has the capacity to turn into virtually any cell type in the body, making them a focal point in the development of cell therapies, the conquering of age-old diseases or even regrowing defective body parts.
LA JOLLA, CA – August 30, 2010 –– An international team led by scientists from The Scripps Research Institute, the Swiss Tropical Institute, the Genomics Institute of the Novartis Research Foundation and the Novartis Institute for Tropical Diseases has discovered a promising new drug candidate that represents a new class of drug to treat malaria. Clinical trials for the compound are planned for later this year.
Montreal, September 3, 2010 – Dr. Éric A. Cohen, Director of the Human Retrovirology research unit at the Institut de recherches cliniques de Montréal (IRCM), and his team published yesterday, in the online open-access journal PLos Pathogens, the results of their most recent research on the role of the Vpr protein in HIV (human immunodeficiency virus) infection and AIDS (acquired autoimmune deficiency syndrome).
It has long been clear that, in evolutionary terms, we share our pallium with other vertebrates, but beyond that was mystery. This is because even invertebrates that are clearly related to us – such as the fish-like amphioxus – appear to have no similar brain structures, nothing that points to a shared evolutionary past. But EMBL scientists have now found brain structures related to the vertebrate pallium in a very distant cousin – the marine ragworm Platynereis dumerilii, a relative of the earthworm - which last shared an ancestor with us around 600 million years ago.
Results of a study reported in the September issue of the Journal of the American Geriatrics Society suggest that Veterans with post-traumatic stress disorder (PTSD) have a greater risk for dementia than Veterans without PTSD, even those who suffered traumatic injuries during combat.
LA JOLLA, CA – August 31, 2010 –– In two closely related studies, two teams of Scripps Research Institute scientists have discovered the underlying mechanisms that activate a type of immune cell in the skin and other organs. The findings may lead to the development of new therapies to treat inflammation, wounds, asthma, and malignant tumors.
Lupus Research Institute-funded researcher Betty Tsao, PhD, at the University of California Los Angeles has discovered that humans—males in particular—with a variant form of the immune receptor gene "Toll Like Receptor 7 (TLR7)" are at increased risk of developing the autoimmune disease systemic lupus erythematosus (lupus). This breakthrough finding offers renewed hope for developing more targeted treatments.
The Department of Computer Science and Technology, Peking University, Beijing, China, has shown that a novel dynamic memory mapping (DMM) model brings about additional flexibility to virtual resource management, leading to the feature-adjustable design of a virtual machine monitor (VMM). The study is reported in Issue 53 (June, 2010) of SCIENCE CHINA Information Sciences because of its significant research value.
Their new approach is the first to passively balance the aerodynamic forces encountered by these miniature flying devices, letting their wings flap asymmetrically in response to gusts of wind, wing damage, and other real-world impediments.
"The ultimate aim is to develop a method which allows humans to unconsciously relate with some parts of the virtual environment more intensely than with others, and that they are encouraged only by their own physiological responses to the virtual reality shown", Christoph Groenegress, co-author of the work and researcher at the University of Barcelona explains to SINC.
People who take oral bisphosphonates for bone disease over five years may be doubling their risk of developing oesophageal cancer (cancer of the gullet), according to a new study published on bmj.com today.